SLC22A8

SLC22A8
Identifiers
Aliases	SLC22A8, OAT3, solute carrier family 22 member 8
External IDs	OMIM: 607581; MGI: 1336187; HomoloGene: 20901; GeneCards: SLC22A8; OMA:SLC22A8 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	63,015,841 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,589,199 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; kidney tubule; ; metanephric glomerulus; ; human kidney; ; testicle; ; renal medulla; ; vena cava; ; vasculature of head; ; gonad; ; Epithelium of choroid plexus;
	Top expressed in
	right kidney; ; human kidney; ; retinal pigment epithelium; ; optic nerve; ; proximal tubule; ; ciliary body; ; olfactory tubercle; ; lumbar subsegment of spinal cord; ; pontine nuclei; ; Epithelium of choroid plexus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium-independent organic anion transmembrane transporter activity; transmembrane transporter activity; inorganic anion exchanger activity; transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	sodium-independent organic anion transport; ion transport; response to toxic substance; transmembrane transport; anion transmembrane transport; inorganic anion transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	9376
	19879
	ENSG00000149452
	ENSMUSG00000063796
	Q8TCC7
	O88909
	NM_001184732; NM_001184733; NM_001184736; NM_004254
	NM_001164634; NM_001164635; NM_031194
	NP_001171661; NP_001171662; NP_001171665; NP_004245
	NP_001158106; NP_001158107; NP_112471
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149452 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063796 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)". Biochemical and Biophysical Research Communications. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.
^ VanWert AL, Gionfriddo MR, Sweet DH (2009). "Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology". Biopharmaceutics & Drug Disposition. 31 (1): 1–71. doi:10.1002/bdd.693. PMID 19953504.
^ EntrezGene 9376

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149452 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063796 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10049739-5] Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)". Biochemical and Biophysical Research Communications. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.

[review-6] VanWert AL, Gionfriddo MR, Sweet DH (2009). "Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology". Biopharmaceutics & Drug Disposition. 31 (1): 1–71. doi:10.1002/bdd.693. PMID 19953504.

[entrez-7] EntrezGene 9376

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