SMC3

SMC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WD5
Identifiers
Aliases	SMC3, BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes 3
External IDs	OMIM: 606062; MGI: 1339795; HomoloGene: 3974; GeneCards: SMC3; OMA:SMC3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 110,567,684 bp[1] End 110,606,048 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 53,588,829 bp[2] End 53,634,264 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone oocyte testicle gonad ganglionic eminence internal globus pallidus Achilles tendon secondary oocyte superior surface of tongue Top expressed in genital tubercle tail of embryo fetal liver hematopoietic progenitor cell ventricular zone mandibular prominence maxillary prominence epiblast hand secondary oocyte somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule motor activity nucleotide binding mediator complex binding chromatin binding protein binding protein heterodimerization activity ATP binding dynein complex binding beta-tubulin binding protein-containing complex binding Cellular component cytosol meiotic cohesin complex nuclear matrix chromosome nucleoplasm lateral element chromatin chromosome, centromeric region nucleus basement membrane intracellular anatomical structure cohesin complex mitotic spindle pole Biological process regulation of DNA replication chromosome organization cellular response to DNA damage stimulus stem cell population maintenance cell division negative regulation of DNA endoreduplication cell cycle DNA repair sister chromatid cohesion mitotic cell cycle meiosis regulation of mitotic spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9126 13006 Ensembl ENSG00000108055 ENSMUSG00000024974 UniProt Q9UQE7 Q9CW03 RefSeq (mRNA) NM_005445 NM_007790 RefSeq (protein) NP_005436 NP_031816 Location (UCSC) Chr 10: 110.57 – 110.61 Mb Chr 19: 53.59 – 53.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Structural maintenance of chromosomes protein 3 (SMC3) is a protein that in humans is encoded by the SMC3 gene.^[5] SMC3 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. In humans, SMC3 is present in all cohesin complexes whereas there are multiple paralogs for the other subunits.

SMC3 is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation.