SMURF2

SMURF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZVD, 2DJY, 2JQZ, 2KXQ, 2LTZ
Identifiers
Aliases	SMURF2, SMAD specific E3 ubiquitin protein ligase 2
External IDs	OMIM: 605532; MGI: 1913563; HomoloGene: 41490; GeneCards: SMURF2; OMA:SMURF2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,662,307 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,811,541 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; secondary oocyte; ; amniotic fluid; ; pylorus; ; saphenous vein; ; lactiferous duct; ; visceral pleura; ; pericardium; ; caput epididymis; ; Achilles tendon;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; secondary oocyte; ; zygote; ; left lung lobe; ; right lung lobe; ; endothelial cell of lymphatic vessel; ; genital tubercle; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity; transforming growth factor beta receptor binding; SMAD binding;
Cellular component	cytosol; membrane; ubiquitin ligase complex; plasma membrane; nucleoplasm; membrane raft; nuclear speck; nucleus; cytoplasm;
Biological process	positive regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; BMP signaling pathway; positive regulation of trophoblast cell migration; ubiquitin-dependent SMAD protein catabolic process; regulation of transforming growth factor beta receptor signaling pathway; protein ubiquitination; negative regulation of transcription, DNA-templated; protein polyubiquitination; Wnt signaling pathway, planar cell polarity pathway; protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of BMP signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	64750
	66313
	ENSG00000108854
	ENSMUSG00000018363
	Q9HAU4
	A2A5Z6
	NM_022739
	NM_025481; NM_001362894
	NP_073576
	NP_079757; NP_001349823
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108854 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018363 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". The Journal of Biological Chemistry. 275 (47): 36818–22. doi:10.1074/jbc.C000580200. PMID 11016919.
^ "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108854 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018363 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11016919-5] Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". The Journal of Biological Chemistry. 275 (47): 36818–22. doi:10.1074/jbc.C000580200. PMID 11016919.

[entrez-6] "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2".

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