SOCS3

SOCS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BBU, 2HMH, 2JZ3, 4GL9
Identifiers
Aliases	SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3
External IDs	OMIM: 604176; MGI: 1201791; HomoloGene: 2941; GeneCards: SOCS3; OMA:SOCS3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,360,077 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	117,860,873 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; vena cava; ; gallbladder; ; saphenous vein; ; pericardium; ; seminal vesicula; ; upper lobe of left lung; ; lower lobe of lung; ; lactiferous duct;
	Top expressed in
	stroma of bone marrow; ; lumbar spinal ganglion; ; granulocyte; ; decidua; ; internal carotid artery; ; mesenteric lymph nodes; ; gastrula; ; islet of Langerhans; ; external carotid artery; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding; phosphotyrosine residue binding; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytosol; cytoplasm; phosphatidylinositol 3-kinase complex; intracellular anatomical structure;
Biological process	regulation of protein phosphorylation; trophoblast giant cell differentiation; intracellular signal transduction; spongiotrophoblast differentiation; placenta blood vessel development; negative regulation of apoptotic process; negative regulation of insulin receptor signaling pathway; regulation of interferon-gamma-mediated signaling pathway; branching involved in labyrinthine layer morphogenesis; protein ubiquitination; positive regulation of cell differentiation; regulation of cell differentiation; regulation of growth; negative regulation of signal transduction; negative regulation of inflammatory response; negative regulation of protein kinase activity; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of tyrosine phosphorylation of STAT protein; post-translational protein modification; cellular response to leukemia inhibitory factor; positive regulation of tyrosine phosphorylation of STAT protein; receptor signaling pathway via JAK-STAT; cytokine-mediated signaling pathway; interleukin-6-mediated signaling pathway; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9021
	12702
	ENSG00000184557
	ENSMUSG00000053113
	O14543; Q6FI39
	O35718
	NM_003955; NM_001378932; NM_001378933
	NM_007707
	NP_003946; NP_001365861; NP_001365862; NP_003946.3
	NP_031733
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene.^[5]^[6] This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

SOCS3 is a conserved gene, found in across the animal kingdom, including Drosophila,^[7] chickens,^[8] and crocodiles.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184557 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053113 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
^ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
^ Stec, Wojciech; Vidal, Oscar; Zeidler, Martin P.; Chernoff, Jonathan (2013). "Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms". Molecular Biology of the Cell. 24 (18): 3000–3009. doi:10.1091/mbc.e13-05-0275. ISSN 1059-1524. PMC 3771960. PMID 23885117.
^ Nakanoh, Shota; Agata, Kiyokazu (2019). "Evolutionary view of pluripotency seen from early development of non-mammalian amniotes". Developmental Biology. 452 (2): 95–103. doi:10.1016/j.ydbio.2019.04.014. ISSN 0012-1606. PMID 31029690.
^ Xia, Tian; Zhang, Lei; Sun, Guolei; Yang, Xiufeng; Zhang, Honghai (2021). "Genomic evidence of adaptive evolution in the reptilian SOCS gene family". PeerJ. 9: e11677. doi:10.7717/peerj.11677. ISSN 2167-8359. PMC 8236234. PMID 34221740.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184557 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053113 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9266833-5] Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.

[pmid9344848-6] Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.

[StecVidal2013-7] Stec, Wojciech; Vidal, Oscar; Zeidler, Martin P.; Chernoff, Jonathan (2013). "Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms". Molecular Biology of the Cell. 24 (18): 3000–3009. doi:10.1091/mbc.e13-05-0275. ISSN 1059-1524. PMC 3771960. PMID 23885117.

[NakanohAgata2019-8] Nakanoh, Shota; Agata, Kiyokazu (2019). "Evolutionary view of pluripotency seen from early development of non-mammalian amniotes". Developmental Biology. 452 (2): 95–103. doi:10.1016/j.ydbio.2019.04.014. ISSN 0012-1606. PMID 31029690.

[XiaZhang2021-9] Xia, Tian; Zhang, Lei; Sun, Guolei; Yang, Xiufeng; Zhang, Honghai (2021). "Genomic evidence of adaptive evolution in the reptilian SOCS gene family". PeerJ. 9: e11677. doi:10.7717/peerj.11677. ISSN 2167-8359. PMC 8236234. PMID 34221740.

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