SOD1

SOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7, 1SOS, 1SPD, 1UXL, 1UXM, 2AF2, 2C9S, 2C9U, 2C9V, 2GBT, 2GBU, 2GBV, 2LU5, 2MP3, 2NNX, 2R27, 2V0A, 2VR6, 2VR7, 2VR8, 2WKO, 2WYT, 2WYZ, 2WZ0, 2WZ5, 2WZ6, 2XJK, 2XJL, 2ZKW, 2ZKX, 2ZKY, 3CQP, 3CQQ, 3ECU, 3ECV, 3ECW, 3GQF, 3GTV, 3GZO, 3GZP, 3GZQ, 3H2P, 3H2Q, 3HFF, 3K91, 3KH3, 3KH4, 3LTV, 3QQD, 3RE0, 3T5W, 4A7G, 4A7Q, 4A7S, 4A7T, 4A7U, 4A7V, 4B3E, 4BCY, 4BCZ, 4BD4, 4FF9, 4MCM, 4MCN, 4NIN, 4NIP, 4OH2, 4XCR
Identifiers
Aliases	SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP
External IDs	OMIM: 147450; MGI: 98351; HomoloGene: 392; GeneCards: SOD1; OMA:SOD1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 31,659,666 bp[1] End 31,668,931 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 51.56 cM Start 90,017,642 bp[2] End 90,023,217 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Pars compacta spinal ganglia lateral nuclear group of thalamus superior vestibular nucleus pars reticulata right lobe of liver Brodmann area 10 right adrenal cortex hypothalamus Top expressed in otolith organ utricle Paneth cell cumulus cell fossa primary oocyte vestibular sensory epithelium Epithelium of choroid plexus facial motor nucleus condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding enzyme binding oxidoreductase activity superoxide dismutase activity protein homodimerization activity zinc ion binding protein binding copper ion binding protein phosphatase 2B binding chaperone binding antioxidant activity identical protein binding superoxide dismutase copper chaperone activity Cellular component cytoplasm cytosol mitochondrial intermembrane space extracellular region mitochondrion neuron projection dendrite cytoplasm dense core granule nucleus myelin sheath peroxisome lysosome extracellular exosome extracellular matrix plasma membrane secretory granule nucleoplasm neuronal cell body mitochondrial matrix cytoplasmic vesicle axon cytoplasm extracellular space protein-containing complex Biological process negative regulation of neuron apoptotic process muscle cell cellular homeostasis response to copper ion placenta development response to amphetamine positive regulation of catalytic activity response to heat response to organic substance anterograde axonal transport spermatogenesis response to ethanol neurofilament cytoskeleton organization heart contraction embryo implantation locomotory behavior thymus development removal of superoxide radicals regulation of GTPase activity transmission of nerve impulse response to antibiotic myeloid cell homeostasis response to oxidative stress reactive oxygen species metabolic process regulation of T cell differentiation in thymus retina homeostasis response to nutrient levels hydrogen peroxide biosynthetic process regulation of protein kinase activity negative regulation of cholesterol biosynthetic process cellular response to potassium ion retrograde axonal transport glutathione metabolic process response to antipsychotic drug negative regulation of apoptotic process cellular response to cadmium ion response to carbon monoxide regulation of blood pressure response to axon injury relaxation of vascular associated smooth muscle ovarian follicle development cellular response to ATP response to hydrogen peroxide superoxide metabolic process peripheral nervous system myelin maintenance response to superoxide positive regulation of cytokine production regulation of multicellular organism growth human ageing platelet degranulation hearing superoxide anion generation auditory receptor cell stereocilium organization regulation of mitochondrial membrane potential positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of apoptotic process positive regulation of superoxide anion generation regulation of organ growth cellular iron ion homeostasis response to reactive oxygen species cellular response to oxidative stress interleukin-12-mediated signaling pathway negative regulation of inflammatory response positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6647 20655 Ensembl ENSG00000142168 ENSMUSG00000022982 UniProt P00441 P08228 RefSeq (mRNA) NM_000454 NM_011434 RefSeq (protein) NP_000445 NP_035564 Location (UCSC) Chr 21: 31.66 – 31.67 Mb Chr 16: 90.02 – 90.02 Mb PubMed search [3] [4]
Wikidata
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Superoxide dismutase [Cu-Zn] also known as superoxide dismutase 1 or hSod1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases.^[5][6] It is implicated in apoptosis, familial amyotrophic lateral sclerosis and Parkinson's disease.^[6][7]