SOS1

SOS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2II0
Identifiers
Aliases	SOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-1
External IDs	OMIM: 182530; MGI: 98354; HomoloGene: 4117; GeneCards: SOS1; OMA:SOS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	39,124,345 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	80,787,882 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; jejunal mucosa; ; tendon of biceps brachii; ; trigeminal ganglion; ; spinal ganglia; ; Achilles tendon; ; seminal vesicula; ; corpus callosum; ; subcutaneous adipose tissue; ; pylorus;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; arcuate nucleus; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; facial motor nucleus; ; lateral hypothalamus; ; anterior horn of spinal cord; ; ventral tegmental area; ; mammillary body; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; GTPase activator activity; protein binding; protein heterodimerization activity; guanyl-nucleotide exchange factor activity; SH3 domain binding;
Cellular component	cytosol; postsynaptic density; plasma membrane; soma; cytoplasm; nucleosome;
Biological process	regulation of pro-B cell differentiation; hair follicle development; insulin receptor signaling pathway; roof of mouth development; heart trabecula morphogenesis; regulation of T cell proliferation; positive regulation of small GTPase mediated signal transduction; blood vessel morphogenesis; epidermal growth factor receptor signaling pathway; vitellogenesis; multicellular organism growth; lymphocyte homeostasis; heart morphogenesis; B cell homeostasis; eyelid development in camera-type eye; MAPK cascade; axon guidance; Fc-epsilon receptor signaling pathway; regulation of T cell differentiation in thymus; pericardium morphogenesis; positive regulation of apoptotic process; midbrain morphogenesis; cardiac atrium morphogenesis; Ras protein signal transduction; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; leukocyte migration; signal transduction; positive regulation of GTPase activity; small GTPase mediated signal transduction; ERBB2 signaling pathway; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6654
	20662
	ENSG00000115904
	ENSMUSG00000024241
	Q07889
	Q62245
	NM_005633; NM_001382394; NM_001382395
	NM_009231
	NP_005624; NP_001369323; NP_001369324
	NP_033257
	Wikidata
View/Edit Human	View/Edit Mouse

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115904 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024241 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DD (October 1993). "Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively". Genomics. 18 (1): 14–19. doi:10.1006/geno.1993.1421. PMID 8276400.
^ Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, et al. (September 2000). "Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21". Genomics. 68 (3): 247–252. doi:10.1006/geno.2000.6285. PMID 10995566.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115904 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024241 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8276400-5] Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DD (October 1993). "Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively". Genomics. 18 (1): 14–19. doi:10.1006/geno.1993.1421. PMID 8276400.

[pmid10995566-6] Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, et al. (September 2000). "Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21". Genomics. 68 (3): 247–252. doi:10.1006/geno.2000.6285. PMID 10995566.

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