SP110

SP110
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1UFN
Identifiers
Aliases	SP110, IFI41, IFI75, IPR1, VODI, SP110 nuclear body protein
External IDs	OMIM: 604457; MGI: 3783243; HomoloGene: 82192; GeneCards: SP110; OMA:SP110 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	230,225,729 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; spleen; ; granulocyte; ; appendix; ; tendon of biceps brachii; ; buccal mucosa cell; ; sural nerve; ; bone marrow cells;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; metal ion binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; viral process; signal transduction; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3431
	101056250
	ENSG00000135899
	n/a
	Q9HB58
	n/a
NM_001185015; NM_004509; NM_004510; NM_080424; NM_001378442;
	NM_001378443; NM_001378444; NM_001378445; NM_001378446; NM_001378447
	n/a
NP_001171944; NP_004500; NP_004501; NP_536349; NP_001365371;
	NP_001365372; NP_001365373; NP_001365374; NP_001365375; NP_001365376
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.^[4]^[5]^[6]

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. doi:10.1016/S0021-9258(20)80544-4. PMID 7693701.
^ Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.
^ ^a ^b "Entrez Gene: SP110 SP110 nuclear body protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135899 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7693701-4] Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. doi:10.1016/S0021-9258(20)80544-4. PMID 7693701.

[pmid10388521-5] Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.

[entrez-6] "Entrez Gene: SP110 SP110 nuclear body protein".

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