Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[5]
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6]
The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000063176 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057342 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Sphingosine kinase 2". Retrieved 2011-12-22.
- ^ [provided by RefSeq, Aug 2011].
- ^ Chen Y, Zhang Y, Rao C, Huang J, Qing Q (2023-03-16). "Deletion of sphingosine kinase 2 attenuates cigarette smoke-mediated chronic obstructive pulmonary disease-like symptoms by reducing lung inflammation". Biomolecules and Biomedicine. 23 (2): 259–270. doi:10.17305/bjbms.2022.8034. ISSN 2831-090X. PMC 10113950. PMID 36226596.