SPTBN1

SPTBN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AA2, 1BKR, 3EDV
Identifiers
Aliases	SPTBN1, ELF, HEL102, SPTB2, betaSpII, spectrin beta, non-erythrocytic 1, DDISBA
External IDs	OMIM: 182790; MGI: 98388; HomoloGene: 2354; GeneCards: SPTBN1; OMA:SPTBN1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	54,671,446 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	30,218,175 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; trigeminal ganglion; ; skin of hip; ; lateral nuclear group of thalamus; ; pars compacta; ; external globus pallidus; ; synovial joint; ; dorsal motor nucleus of vagus nerve; ; superior vestibular nucleus; ; pars reticulata;
	Top expressed in
	right lung; ; right lung lobe; ; facial motor nucleus; ; carotid body; ; left lung; ; iris; ; endothelial cell of lymphatic vessel; ; vestibular membrane of cochlear duct; ; anterior horn of spinal cord; ; gastrula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calmodulin binding; structural constituent of cytoskeleton; protein binding; ankyrin binding; GTPase binding; actin binding; phospholipid binding; protein-containing complex binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; M band; cytosol; spectrin; membrane; cortical cytoskeleton; plasma membrane; cuticular plate; nucleolus; axolemma; spectrin-associated cytoskeleton; extracellular exosome; cytoskeleton; nucleus; postsynaptic density; protein-containing complex; postsynapse; glutamatergic synapse;
Biological process	common-partner SMAD protein phosphorylation; mitotic cytokinesis; MAPK cascade; axon guidance; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to plasma membrane; actin filament capping; plasma membrane organization; membrane assembly; regulation of protein localization to plasma membrane; Golgi to plasma membrane protein transport; cytoskeleton organization; protein localization to plasma membrane; regulation of molecular function; regulation of SMAD protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	6711
	20742
	ENSG00000115306
	ENSMUSG00000020315
	Q01082
	Q62261
	NM_003128; NM_178313
	NM_009260; NM_175836
	NP_003119; NP_842565
	NP_033286; NP_787030
	Wikidata
View/Edit Human	View/Edit Mouse

Spectrin beta chain, brain 1 is a protein that in humans is encoded by the SPTBN1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115306 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020315 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SPTBN1 spectrin, beta, non-erythrocytic 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115306 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020315 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SPTBN1 spectrin, beta, non-erythrocytic 1".

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