ST8SIA2

ST8SIA2
Identifiers
Aliases	ST8SIA2, HsT19690, SIAT8B, ST8SIA-II, STX, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, SIAT8-B, ST8SiaII
External IDs	OMIM: 602546; MGI: 106020; HomoloGene: 4384; GeneCards: ST8SIA2; OMA:ST8SIA2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	92,468,728 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	73,663,438 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; testicle; ; left ventricle; ; apex of heart; ; prefrontal cortex; ; retinal pigment epithelium; ; hypothalamus; ; gonad; ; cingulate gyrus;
	Top expressed in
	Rostral migratory stream; ; internal carotid artery; ; external carotid artery; ; ganglionic eminence; ; medial ganglionic eminence; ; vestibular sensory epithelium; ; epithelium of lens; ; neural tube; ; ventricular zone; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; sialyltransferase activity; sialic acid binding; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;
Cellular component	integral component of membrane; recycling endosome; Golgi apparatus; membrane; Golgi membrane; early endosome;
Biological process	N-glycan processing; ganglioside biosynthetic process; nervous system development; protein glycosylation; oligosaccharide metabolic process; sialylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8128
	20450
	ENSG00000140557
	ENSMUSG00000025789
	Q92186
	O35696
	NM_006011; NM_001330416
	NM_009181
	NP_001317345; NP_006002; NP_006002.1
	NP_033207
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140557 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025789 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scheidegger EP, Sternberg LR, Roth J, Lowe JB (September 1995). "A human STX cDNA confers polysialic acid expression in mammalian cells". The Journal of Biological Chemistry. 270 (39): 22685–8. doi:10.1074/jbc.270.39.22685. PMID 7559389.
^ "Entrez Gene: ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140557 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025789 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7559389-5] Scheidegger EP, Sternberg LR, Roth J, Lowe JB (September 1995). "A human STX cDNA confers polysialic acid expression in mammalian cells". The Journal of Biological Chemistry. 270 (39): 22685–8. doi:10.1074/jbc.270.39.22685. PMID 7559389.

[entrez-6] "Entrez Gene: ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2".

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