STAT protein

Domains and covalent modification sites of STAT proteins.
STAT protein, all-alpha domain
Identifiers
SymbolSTAT_alpha
PfamPF01017
InterProIPR013800
SCOP21bgf / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
STAT protein, DNA binding domain
Identifiers
SymbolSTAT_bind
PfamPF02864
InterProIPR013801
SCOP21bgf / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
STAT protein, protein interaction domain
Identifiers
SymbolSTAT_int
PfamPF02865
InterProIPR013799
SCOP21bgf / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1yvlA:2-122, 1bgfA:2-122
Dictyostelium STAT, coiled coil
structure of an activated dictyostelium stat in its DNA-unbound form
Identifiers
SymbolDict-STAT-coil
PfamPF09267
InterProIPR015347
SCOP21uur / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis which enhances the survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.