STAU1

STAU1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DKK
Identifiers
Aliases	STAU1, PPP1R150, STAU, staufen double-stranded RNA binding protein 1
External IDs	OMIM: 601716; MGI: 1338864; HomoloGene: 3384; GeneCards: STAU1; OMA:STAU1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 49,113,339 bp[1] End 49,188,367 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 166,789,469 bp[2] End 166,838,219 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule secondary oocyte amniotic fluid parietal pleura pancreatic ductal cell visceral pleura endothelial cell germinal epithelium palpebral conjunctiva glomerulus Top expressed in tail of embryo genital tubercle cumulus cell molar primary oocyte secondary oocyte ventricular zone zygote neural tube maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 1 binding protein binding double-stranded RNA binding RNA binding Cellular component cytoplasm cell body rough endoplasmic reticulum membrane plasma membrane microtubule associated complex soma dendrite endoplasmic reticulum cytoplasmic ribonucleoprotein granule neuron projection cytoplasmic stress granule extracellular exosome cytosol glutamatergic synapse Biological process positive regulation of long-term synaptic potentiation positive regulation by virus of viral protein levels in host cell cellular response to oxidative stress positive regulation of viral genome replication modulation of chemical synaptic transmission modification of postsynaptic structure viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6780 20853 Ensembl ENSG00000124214 ENSMUSG00000039536 UniProt O95793 Q9Z108 RefSeq (mRNA) NM_001037328 NM_004602 NM_017452 NM_017453 NM_017454 NM_001319134 NM_001319135 NM_001322927 NM_001322928 NM_001322929 NM_001322930 NM_001322931 NM_001322932 NM_001322933 NM_001109905 NM_001109906 NM_001291160 NM_011490 RefSeq (protein) NP_001032405 NP_001306063 NP_001306064 NP_001309856 NP_001309857 NP_001309858 NP_001309859 NP_001309860 NP_001309861 NP_001309862 NP_004593 NP_059346 NP_059347 NP_059348 NP_001103375 NP_001103376 NP_001278089 NP_035620 Location (UCSC) Chr 20: 49.11 – 49.19 Mb Chr 2: 166.79 – 166.84 Mb PubMed search [3] [4]
Wikidata
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Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene.^[5][6][7]

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.^[7]

STAU1 is associated with stress granules.^[8]