STK11

STK11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WTK, 4ZDR
Identifiers
Aliases	STK11, LKB1, PJS, hLKB1, serine/threonine kinase 11
External IDs	OMIM: 602216; MGI: 1341870; HomoloGene: 393; GeneCards: STK11; OMA:STK11 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,228,431 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,966,516 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; muscle of thigh; ; gastrocnemius muscle; ; granulocyte; ; stromal cell of endometrium; ; right hemisphere of cerebellum; ; tendon of biceps brachii; ; mucosa of transverse colon; ; apex of heart;
	Top expressed in
	Ileal epithelium; ; granulocyte; ; saccule; ; ventricular zone; ; muscle of thigh; ; otic placode; ; neural layer of retina; ; lip; ; zygote; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; LRR domain binding; protein kinase activity; p53 binding; protein kinase activator activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding;
Cellular component	cytoplasm; membrane; mitochondrion; extracellular exosome; TCR signalosome; nucleus; nucleoplasm; cytosol;
Biological process	response to ionizing radiation; positive regulation of transforming growth factor beta receptor signaling pathway; dendrite extension; TCR signalosome assembly; axonogenesis; glucose homeostasis; positive regulation of autophagy; phosphorylation; negative regulation of lipid biosynthetic process; positive regulation of axonogenesis; cellular response to DNA damage stimulus; regulation of dendrite morphogenesis; autophagy; protein phosphorylation; Golgi localization; regulation of Wnt signaling pathway; vasculature development; anoikis; cellular response to UV-B; negative regulation of cell growth; regulation of cell growth; tissue homeostasis; establishment of cell polarity; positive thymic T cell selection; positive regulation of peptidyl-tyrosine phosphorylation; regulation of protein kinase B signaling; canonical Wnt signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; protein autophosphorylation; cell cycle; negative regulation of epithelial cell proliferation involved in prostate gland development; T cell receptor signaling pathway; spermatogenesis; activation of protein kinase activity; negative regulation of TORC1 signaling; negative regulation of cell population proliferation; positive regulation of protein localization to nucleus; apoptotic process; regulation of signal transduction by p53 class mediator; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; cell differentiation; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; negative regulation of canonical Wnt signaling pathway; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6794
	20869
	ENSG00000118046
	ENSMUSG00000003068
	Q15831
	Q9WTK7
	NM_000455
	NM_001301853; NM_001301854; NM_011492
	NP_000446
	NP_001288782; NP_001288783; NP_035622
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118046 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003068 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase". Nature Genetics. 18 (1): 38–43. doi:10.1038/ng0198-38. PMID 9425897. S2CID 28986057.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118046 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003068 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9425897-5] Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase". Nature Genetics. 18 (1): 38–43. doi:10.1038/ng0198-38. PMID 9425897. S2CID 28986057.

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