STK25

STK25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XIK, 3W8H, 4NZW
Identifiers
Aliases	STK25, SOK1, YSK1, serine/threonine kinase 25
External IDs	OMIM: 602255; MGI: 1891699; HomoloGene: 48428; GeneCards: STK25; OMA:STK25 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,509,730 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,586,381 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; right frontal lobe; ; apex of heart; ; ventricular zone; ; anterior pituitary; ; ganglionic eminence;
	Top expressed in
	spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; spermatid; ; superior frontal gyrus; ; ventricular zone; ; genital tubercle; ; muscle of thigh; ; right ventricle; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein homodimerization activity; metal ion binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity; MAP kinase kinase kinase kinase activity;
Cellular component	cytoplasm; Golgi apparatus; Golgi membrane; extracellular exosome;
Biological process	intrinsic apoptotic signaling pathway in response to hydrogen peroxide; phosphorylation; response to oxidative stress; positive regulation of axonogenesis; establishment of Golgi localization; Golgi reassembly; establishment or maintenance of cell polarity; protein phosphorylation; Golgi localization; protein autophosphorylation; response to hydrogen peroxide; signal transduction; positive regulation of stress-activated MAPK cascade; MAPK cascade; regulation of mitotic cell cycle; regulation of apoptotic process; neuron projection morphogenesis; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	10494
	59041
	ENSG00000115694
	ENSMUSG00000026277
	O00506
	Q9Z2W1
NM_001271977; NM_001271978; NM_001271979; NM_001271980; NM_001282305;
	NM_001282306; NM_001282307; NM_001282308; NM_006374
	NM_021537
NP_001258906; NP_001258907; NP_001258908; NP_001258909; NP_001269234;
	NP_001269235; NP_001269236; NP_001269237; NP_006365
	NP_067512
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115694 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026277 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J. 15 (17): 4537–46. doi:10.1002/j.1460-2075.1996.tb00831.x. PMC 452183. PMID 8887545.
^ Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885. S2CID 27210425.
^ Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
^ "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026277 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8887545-5] Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J. 15 (17): 4537–46. doi:10.1002/j.1460-2075.1996.tb00831.x. PMC 452183. PMID 8887545.

[pmid9160885-6] Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene. 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885. S2CID 27210425.

[pmid15037601-7] Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.

[entrez-8] "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".

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