STK4

STK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3COM, 4NR2, 4OH8, 2JO8
Identifiers
Aliases	STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
External IDs	OMIM: 604965; MGI: 1929004; HomoloGene: 55965; GeneCards: STK4; OMA:STK4 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,080,021 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,997,444 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; buccal mucosa cell; ; blood; ; monocyte; ; superficial temporal artery; ; trabecular bone; ; pylorus; ; tonsil; ; lymph node; ; saphenous vein;
	Top expressed in
	mesenteric lymph nodes; ; blood; ; right lung lobe; ; fossa; ; spleen; ; condyle; ; left lung lobe; ; thymus; ; stroma of bone marrow; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein dimerization activity; protein homodimerization activity; transcription factor binding; protein serine/threonine kinase activator activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; ATP binding; magnesium ion binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol; nuclear body; protein-containing complex;
Biological process	regulation of cell differentiation involved in embryonic placenta development; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of protein phosphorylation; intracellular signal transduction; phosphorylation; protein stabilization; hippo signaling; keratinocyte differentiation; positive regulation of peptidyl-serine phosphorylation; endocardium development; protein phosphorylation; primitive hemopoiesis; central nervous system development; peptidyl-serine phosphorylation; cell morphogenesis; positive regulation of apoptotic process; branching involved in blood vessel morphogenesis; protein autophosphorylation; positive regulation of protein binding; cell differentiation involved in embryonic placenta development; positive regulation of fat cell differentiation; negative regulation of organ growth; neural tube formation; negative regulation of canonical Wnt signaling pathway; signal transduction; negative regulation of cell population proliferation; hepatocyte apoptotic process; apoptotic process; positive regulation of protein serine/threonine kinase activity; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; positive regulation of vascular associated smooth muscle cell apoptotic process; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	6789
	58231
	ENSG00000101109
	ENSMUSG00000018209
	Q13043
	Q9JI11
	NM_006282; NM_001352385
	NM_021420
	NP_006273; NP_001339314
	NP_067395
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101109 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018209 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
^ Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236.
^ Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. Bibcode:2001PNAS...9810148U. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101109 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018209 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8816758-5] Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. Bibcode:1996PNAS...9310099T. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.

[pmid9545236-6] Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236.

[pmid11517310-7] Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. Bibcode:2001PNAS...9810148U. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310.

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