SULT2B1

SULT2B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q1Q, 1Q1Z, 1Q20, 1Q22
Identifiers
Aliases	SULT2B1, HSST2, sulfotransferase family 2B member 1, ARCI14
External IDs	OMIM: 604125; MGI: 1926342; HomoloGene: 49487; GeneCards: SULT2B1; OMA:SULT2B1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,599,425 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,434,093 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; gingival epithelium; ; skin of arm; ; mucosa of pharynx; ; oral cavity; ; vulva; ; skin of thigh; ; epithelium of esophagus; ; cervix epithelium;
	Top expressed in
	lip; ; esophagus; ; jejunum; ; duodenum; ; skin of abdomen; ; skin of external ear; ; intestinal villus; ; ileum; ; skin of back; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; protein binding; alcohol sulfotransferase activity; steroid sulfotransferase activity; nucleic acid binding; cholesterol binding; steroid hormone binding;
Cellular component	extracellular exosome; endoplasmic reticulum; intracellular membrane-bounded organelle; nucleus; cytoplasm; cytosol;
Biological process	steroid metabolic process; sulfate assimilation; lipid metabolism; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cholesterol metabolic process; negative regulation of cell population proliferation; positive regulation of epidermal cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6820
	54200
	ENSG00000088002
	ENSMUSG00000003271
	O00204
	O35400
	NM_004605; NM_177973
	NM_017465; NM_001360784
	NP_004596; NP_814444
	NP_059493; NP_001347713
	Wikidata
View/Edit Human	View/Edit Mouse

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.^[5]^[6]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088002 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003271 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998). "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene". Genomics. 53 (3): 284–95. doi:10.1006/geno.1998.5518. PMID 9799594.
^ ^a ^b "Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088002 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003271 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799594-5] Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998). "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene". Genomics. 53 (3): 284–95. doi:10.1006/geno.1998.5518. PMID 9799594.

[entrez-6] "Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1".

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