SUZ12

SUZ12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IJ7, 5IJ8, 5HYN
Identifiers
Aliases	SUZ12, CHET9, JJAZ1, SUZ12 polycomb repressive complex 2 subunit, polycomb repressive complex 2 subunit, IMMAS
External IDs	OMIM: 606245; MGI: 1261758; HomoloGene: 32256; GeneCards: SUZ12; OMA:SUZ12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	32,001,038 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	79,924,949 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; mucosa of paranasal sinus; ; buccal mucosa cell; ; Epithelium of choroid plexus; ; pylorus; ; renal medulla; ; seminal vesicula; ; hair follicle; ; cartilage tissue; ; ventricular zone;
	Top expressed in
	medullary collecting duct; ; zygote; ; secondary oocyte; ; renal corpuscle; ; primary oocyte; ; atrioventricular valve; ; saccule; ; ventricular zone; ; tail of embryo; ; otic placode;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	histone methyltransferase activity; sequence-specific DNA binding; chromatin binding; metal ion binding; methylated histone binding; protein binding; RNA binding; RNA polymerase II core promoter sequence-specific DNA binding; chromatin DNA binding; promoter-specific chromatin binding; histone methyltransferase activity (H3-K27 specific); RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	sex chromatin; ESC/E(Z) complex; nucleoplasm; protein-DNA complex; nucleolus; nucleus; RSC-type complex; nuclear body;
Biological process	negative regulation of cell differentiation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of gene expression, epigenetic; positive regulation of cell population proliferation; histone methylation; histone ubiquitination; regulation of transcription, DNA-templated; histone H3-K27 methylation; negative regulation of G0 to G1 transition; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	23512
	52615
	ENSG00000178691
	ENSMUSG00000017548
	Q15022
	Q80U70
	NM_015355; NM_001321207
	NM_001163018; NM_199196
	NP_001308136; NP_056170
	NP_001156490; NP_954666
	Wikidata
View/Edit Human	View/Edit Mouse

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178691 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017548 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J (May 2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6348–53. Bibcode:2001PNAS...98.6348K. doi:10.1073/pnas.101132598. PMC 33471. PMID 11371647.
^ Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB (December 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction. 136 (6): 777–85. doi:10.1530/REP-08-0045. PMID 18784248.
^ "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178691 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017548 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8590280-5] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.

[pmid11371647-6] Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J (May 2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6348–53. Bibcode:2001PNAS...98.6348K. doi:10.1073/pnas.101132598. PMC 33471. PMID 11371647.

[pmid18784248-7] Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB (December 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction. 136 (6): 777–85. doi:10.1530/REP-08-0045. PMID 18784248.

[entrez-8] "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)".

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