SYM-2081

SYM-2081
Names
	IUPAC name (2S,4R)-2-Amino-4-methylpentanedioic acid
	Other names (2S,4R)-4-Methylglutamic acid
Identifiers
CAS Number	31137-74-3; 77842-39-8;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:228160;
ChEMBL	ChEMBL288166;
ChemSpider	86558;
IUPHAR/BPS	10821708;
PubChem CID	95883;
CompTox Dashboard (EPA)	DTXSID901300044 ;
	InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1 Key: KRKRAOXTGDJWNI-DMTCNVIQSA-N;
	SMILES C[C@H](C[C@@H](C(=O)O)N)C(=O)O;
Properties
Chemical formula	C6H11NO4
Molar mass	161.157 g·mol−1
Appearance	White solid
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

SYM-2081 is a highly selective agonist for the kainate receptor. This potent agonist has nearly 3,000 fold- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors, respectively.^[1] Given its potency and selectivity, it is a useful ligand for studying the role of kainate receptors in the central nervous system.^[2]

^ "SYM 2081". R&D Systems.
^ Donevan, S. D.; Beg, A.; Gunther, J. M.; Twyman, R. E. (May 1998). "The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 539–545. ISSN 0022-3565. PMID 9580595.