S cell

S cell
S cell
Details
Location	Jejunum and duodenum
Function	Secretin secretion
Identifiers
Latin	endocrinocytus S
TH	H3.04.02.0.00037
FMA	62936
	Anatomical terms of microanatomy [edit on Wikidata]

S cells are cells which release secretin, found in the jejunum and duodenum.^[1] They are stimulated by a drop in pH to 4 or below in the small intestine's lumen. The released secretin will increase the secretion of bicarbonate (HCO₃⁻) into the lumen, via the pancreas. This is primarily accomplished by an increase in cyclic AMP that activates CFTR to release chloride anions into the lumen. The luminal Cl⁻ is then involved in a bicarbonate transporter protein exchange, in which the chloride is reabsorbed by the cell and HCO₃⁻ is secreted into the lumen. S cells are also one of the main producers of cyclosamatin.

^ Afroze, Syeda; Meng, Fanyin; Jensen, Kendal; McDaniel, Kelly; Rahal, Kinan; Onori, Paolo; Gaudio, Eugenio; Alpini, Gianfranco; Glaser, Shannon S. (October 2013). "The physiological roles of secretin and its receptor". Annals of Translational Medicine. 1 (3): 29. doi:10.3978/j.issn.2305-5839.2012.12.01. ISSN 2305-5839. PMC 4200670. PMID 25332973.

[1] Afroze, Syeda; Meng, Fanyin; Jensen, Kendal; McDaniel, Kelly; Rahal, Kinan; Onori, Paolo; Gaudio, Eugenio; Alpini, Gianfranco; Glaser, Shannon S. (October 2013). "The physiological roles of secretin and its receptor". Annals of Translational Medicine. 1 (3): 29. doi:10.3978/j.issn.2305-5839.2012.12.01. ISSN 2305-5839. PMC 4200670. PMID 25332973.

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