Saccharopolyspora erythraea

Saccharopolyspora erythraea
Scientific classification
Domain:	Bacteria
Phylum:	Actinomycetota
Class:	Actinomycetia
Order:	Pseudonocardiales
Family:	Pseudonocardiaceae
Genus:	Saccharopolyspora
Species:	S. erythraea
Binomial name
	Saccharopolyspora erythraea; (Waksman 1923) Labeda 1987
Synonyms
	"Actinomyces erythreus" Waksman 1923; Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 (Approved Lists 1980);

Saccharopolyspora erythraea is a species of actinomycete bacteria within the genus Saccharopolyspora.

Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin.^[2] Cytochrome P450 eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B.^[3]^[4]

Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis.^[5]

^ Labeda, David P. (1987-01-01). "Transfer of the Type Strain of Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 to the Genus Saccharopolyspora Lacey and Goodfellow 1975 as Saccharopolyspora erythraea sp. nov., and Designation of a Neotype Strain for Streptomyces erythraeus". International Journal of Systematic Bacteriology. 37 (1): 19. doi:10.1099/00207713-37-1-19.
^ Oliynyk, Markiyan; Samborskyy, Markiyan; Lester, John B.; Mironenko, Tatiana; Scott, Nataliya; Dickens, Shilo; Haydock, Stephen F.; Leadlay, Peter F. (2007). "Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338". Nature Biotechnology. 25 (4): 447–453. doi:10.1038/nbt1297. PMID 17369815.
^ Cupp-Vickery, JR; Poulos, TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature Structural Biology. 2 (2): 144–53. doi:10.1038/nsb0295-144. PMID 7749919. S2CID 22536232.
^ Harris, DL (20 September 2002). "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450 eryF". Journal of Inorganic Biochemistry. 91 (4): 568–85. doi:10.1016/s0162-0134(02)00477-4. PMID 12237223.
^ Liu, Wei-Bing; Shi, Yang; Yao, Li-Li; Zhou, Ying; Ye, Bang-Ce (2013-01-01). "Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea". PLOS ONE. 8 (11): e80676. Bibcode:2013PLoSO...880676L. doi:10.1371/journal.pone.0080676. ISSN 1932-6203. PMC 3827479. PMID 24236194.

[1] Labeda, David P. (1987-01-01). "Transfer of the Type Strain of Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 to the Genus Saccharopolyspora Lacey and Goodfellow 1975 as Saccharopolyspora erythraea sp. nov., and Designation of a Neotype Strain for Streptomyces erythraeus". International Journal of Systematic Bacteriology. 37 (1): 19. doi:10.1099/00207713-37-1-19.

[2] Oliynyk, Markiyan; Samborskyy, Markiyan; Lester, John B.; Mironenko, Tatiana; Scott, Nataliya; Dickens, Shilo; Haydock, Stephen F.; Leadlay, Peter F. (2007). "Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338". Nature Biotechnology. 25 (4): 447–453. doi:10.1038/nbt1297. PMID 17369815.

[3] Cupp-Vickery, JR; Poulos, TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature Structural Biology. 2 (2): 144–53. doi:10.1038/nsb0295-144. PMID 7749919. S2CID 22536232.

[4] Harris, DL (20 September 2002). "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450 eryF". Journal of Inorganic Biochemistry. 91 (4): 568–85. doi:10.1016/s0162-0134(02)00477-4. PMID 12237223.

[5] Liu, Wei-Bing; Shi, Yang; Yao, Li-Li; Zhou, Ying; Ye, Bang-Ce (2013-01-01). "Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea". PLOS ONE. 8 (11): e80676. Bibcode:2013PLoSO...880676L. doi:10.1371/journal.pone.0080676. ISSN 1932-6203. PMC 3827479. PMID 24236194.

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