Samuel Irving Newhouse may refer to:
- Samuel Irving Newhouse Sr. (1895–1979), publisher, founder of Advance Publications empire, which controls Condé Nast Publications
- Samuel Irving Newhouse Jr. (1927-2017), nicknamed Si Newhouse, chairman and CEO of Advance Publications and chairman of Condé Nast
- Samuel Irving Newhouse IV, featured in the documentary Born Rich (2003)