Samuel Wilkeson | |
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| 5th Mayor of Buffalo, New York | |
| In office 1836–1837 | |
| Preceded by | Hiram Pratt |
| Succeeded by | Josiah Trowbridge |
| Member of the New York State Senate for the 8th district | |
| In office January 1, 1825 – December 31, 1828 | |
| Preceded by | David Eason |
| Succeeded by | Moses Hayden |
| Member of the New York State Assembly for the Erie County | |
| In office January 1, 1824 – December 31, 1824 | |
| Preceded by | Ebenezer F. Norton |
| Succeeded by | Calvin Fillmore |
| Personal details | |
| Born | June 1, 1781 Carlisle, Pennsylvania |
| Died | July 7, 1848 (aged 67) near Tellico Plains, Tennessee |
| Political party | People's Party, Clintonian |
| Spouse(s) | Jane Oram Sarah St. John Mary Peters |
| Relations | Samuel Wilkeson Jr. (son), Frank Wilkeson (grandson) |
| Children | 6 |
| Signature |  |
Samuel Wilkeson (June 1, 1781 – July 7, 1848) was a merchant, politician, and judge who served as mayor of Buffalo, New York.