25°25′19″N 101°00′07″W / 25.422°N 101.002°W San Esteban de Nueva Tlaxcala was a Tlaxcalan municipality in what is now the Mexican state of Coahuila. San Esteban was the northernmost of the six Tlaxcalan colonies established in 1591 at the behest of the Viceroy of New Spain, Luis de Velasco; its founders came from Tizatlan. In 1834, San Esteban was merged into the adjoining city of Saltillo.
On the sparsely settled northeastern frontier of Mexico, menaced by hostile indigenous people (Indians), the Tlaxcalans were allies of the Spanish settlers against the indigenous of the region, but also stood apart with an independent society. San Esteban was often in legal controversies with the Spanish settlers of Saltillo.[1]