Sanguine is a red pigment.
Sanguine may also refer to:
- Sanguine, a personality type, one of the four temperaments
- Sanguine (band), an alt-metal band
- Sanguine (heraldry), a tincture in heraldry
- Sanguine (transmitter), an antenna of the US Navy
- Sanguine, a fruit, type of blood orange
- HMS Sanguine (P266), a submarine
- Project Sanguine, a research project for radio communication with submarines