| Sant'Onofrio Altarpiece | |
|---|---|
 | |
| Artist | Luca Signorelli |
| Year | 1484 |
| Type | Tempera and oil on panel |
| Dimensions | 221 cm × 189 cm (87 in × 74 in) |
| Location | Museo dell'Opera del Duomo, Perugia, Italy |
The Sant'Onofrio Altarpiece is a painting by the Italian Renaissance painter Luca Signorelli, housed in the Museo dell'Opera del Duomo in the Cathedral of Perugia, Italy. It was painted for the church in 1484, commissioned by bishop Jacopo Vagnucci, a native of Cortona, Signorelli's birthplace.