Santa Rosa Sound is a sound connecting Pensacola Bay and Choctawhatchee Bay in Florida. The northern shore consists of the Fairpoint Peninsula and portions of the mainland in Santa Rosa County and Okaloosa County. It is bounded to the south by Santa Rosa Island (also known as Okaloosa Island in the easternmost region of the sound), separating it from the Gulf of Mexico.
The Gulf Intracoastal Waterway between Pensacola Beach and Fort Walton Beach is routed through the sound.