| Santee National Wildlife Refuge | |
|---|---|
IUCN category IV (habitat/species management area) | |
 Bald cypress forest in autumn, Cuddo Unit of refuge | |
  Map of the United States | |
| Location | Clarendon County, South Carolina, United States |
| Nearest city | Summerton, South Carolina |
| Coordinates | 33°31′00″N 80°19′30″W / 33.51667°N 80.32500°W |
| Area | 15,000 acres (61 km2) |
| Established | 1941 |
| Governing body | U.S. Fish and Wildlife Service |
| Website | Santee National Wildlife Refuge |
Santee National Wildlife Refuge is a 15,000-acre (61 km2) refuge alongside Lake Marion, an impoundment of the Santee River of Clarendon County, South Carolina.