Satraplatin

Satraplatin
Clinical data
Other namesBMY 45594
BMS 182751
(OC-6-43)-bis(acetato)amminedichlorocyclohexylamine platinum(IV)
Routes of
administration		Oral
ATC code
Identifiers
  • (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
CAS Number
PubChem CID
UNII
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H22Cl2N2O4Pt
Molar mass500.28 g·mol−1
3D model (JSmol)
  • Cl[Pt-2](Cl)(OC(=O)C)(OC(=O)C)([NH3+])[NH2+]C1CCCCC1
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Satraplatin (INN, codenamed JM216) is a platinum-based antineoplastic agent that was under investigation as a treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration.[1] First mentioned in the medical literature in 1993,[2] satraplatin is the first orally active platinum-based chemotherapeutic drug;[3] other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously.

The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing.[4]

  1. ^ Wheate NJ, Walker S, Craig GE, Oun R (September 2010). "The status of platinum anticancer drugs in the clinic and in clinical trials". Dalton Transactions. 39 (35): 8113–8127. doi:10.1039/C0DT00292E. hdl:2123/14271. PMID 20593091. S2CID 205766376.
  2. ^ Kelland LR, Abel G, McKeage MJ, Jones M, Goddard PM, Valenti M, et al. (June 1993). "Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): an orally active platinum drug" (PDF). Cancer Research. 53 (11): 2581–2586. PMID 8388318.
  3. ^ Choy H, Park C, Yao M (March 2008). "Current status and future prospects for satraplatin, an oral platinum analogue". Clinical Cancer Research. 14 (6): 1633–1638. doi:10.1158/1078-0432.CCR-07-2176. PMID 18347164.
  4. ^ Satraplatin — Spectrum Pharmaceuticals Archived 2007-07-04 at the Wayback Machine