Sclerostin

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Sclerostin
Sclerostin
Identifiers
Symbol	Sclerostin
Pfam	PF05463
InterPro	IPR008835
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

SOST
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K8P, 3SOV
Identifiers
Aliases	SOST, CDD, SOST1, VBCH, DAND6, sclerostin, Sclerostin
External IDs	OMIM: 605740; MGI: 1921749; HomoloGene: 11542; GeneCards: SOST; OMA:SOST - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,758,791 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,857,841 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; Descending thoracic aorta; ; testicle; ; tibia; ; ascending aorta; ; popliteal artery; ; right coronary artery; ; tibial arteries; ; gonad; ; human kidney;
	Top expressed in
	tunica media of zone of aorta; ; thoracic aorta; ; ascending aorta; ; aortic valve; ; aortic arch; ; pulmonary trunk; ; tail of embryo; ; calvaria; ; brachiocephalic artery; ; trunk of common carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription factor binding; protein binding; heparin binding;
Cellular component	extracellular matrix; Golgi apparatus; extracellular region; extracellular space; protein-containing complex; collagen-containing extracellular matrix;
Biological process	Wnt signaling pathway; negative regulation of BMP signaling pathway; positive regulation of transcription, DNA-templated; response to mechanical stimulus; negative regulation of protein-containing complex assembly; negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; cellular response to parathyroid hormone stimulus; ossification; negative regulation of ossification; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50964
	74499
	ENSG00000167941
	ENSMUSG00000001494
	Q9BQB4
	Q99P68
	NM_025237
	NM_024449
	NP_079513
	NP_077769
	Wikidata
View/Edit Human	View/Edit Mouse

Sclerostin is a protein that in humans is encoded by the SOST gene.^[5] It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues,^[6] and has anti-anabolic effects on bone formation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167941 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001494 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR, Proll S, et al. (March 2001). "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein". American Journal of Human Genetics. 68 (3): 577–89. doi:10.1086/318811. PMC 1274471. PMID 11179006.
^ Hernandez P, Whitty C, John Wardale R, Henson FM (April 2014). "New insights into the location and form of sclerostin". Biochemical and Biophysical Research Communications. 446 (4): 1108–13. doi:10.1016/j.bbrc.2014.03.079. PMID 24667598.
^ "Entrez Gene: SOST sclerosteosis".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167941 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001494 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11179006-5] Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR, Proll S, et al. (March 2001). "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein". American Journal of Human Genetics. 68 (3): 577–89. doi:10.1086/318811. PMC 1274471. PMID 11179006.

[6] Hernandez P, Whitty C, John Wardale R, Henson FM (April 2014). "New insights into the location and form of sclerostin". Biochemical and Biophysical Research Communications. 446 (4): 1108–13. doi:10.1016/j.bbrc.2014.03.079. PMID 24667598.

[entrez-7] "Entrez Gene: SOST sclerosteosis".

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