Secnidazole

Secnidazole
Clinical data
Trade names	Solosec
Other names	PM 185184, RP 14539
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Secnidazole;
Routes of; administration	Oral
ATC code	P01AB07 (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name 1-(2-Methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol;
CAS Number	3366-95-8 ;
PubChem CID	71815;
ChemSpider	64839 ;
UNII	R3459K699K;
KEGG	D07353 ;
ChEBI	CHEBI:140628;
ChEMBL	ChEMBL498847 ;
CompTox Dashboard (EPA)	DTXSID3045934 ;
ECHA InfoCard	100.020.123
Chemical and physical data
Formula	C7H11N3O3
Molar mass	185.183 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-] [N+](=O)c1cnc(n1CC(O)C)C;
	InChI InChI=1S/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3 ; Key:KPQZUUQMTUIKBP-UHFFFAOYSA-N ;
	(what is this?) (verify)

Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective. Structurally it actually methyl-metronidazole. Effectiveness in the treatment of dientamoebiasis has been reported.^[1] It has also been tested against Atopobium vaginae.^[2]

In the United States, secnidazole is FDA approved for the treatment of bacterial vaginosis and trichomoniasis in adult women.^[3]

^ Girginkardeşler N, Coşkun S, Cüneyt Balcioğlu I, Ertan P, Ok UZ (February 2003). "Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole". Clinical Microbiology and Infection. 9 (2): 110–3. doi:10.1046/j.1469-0691.2003.00504.x. PMID 12588330.
^ De Backer E, Dubreuil L, Brauman M, Acar J, Vaneechoutte M (May 2010). "In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis". Clinical Microbiology and Infection. 16 (5): 470–2. doi:10.1111/j.1469-0691.2009.02852.x. PMID 19548924.
^ Muzny CA, Van Gerwen OT (April 2022). "Secnidazole for Trichomoniasis in Women and Men". Sex Med Rev. 10 (2): 255–262. doi:10.1016/j.sxmr.2021.12.004. PMC 11019772. PMID 35153156. S2CID 246755406.

[1] Girginkardeşler N, Coşkun S, Cüneyt Balcioğlu I, Ertan P, Ok UZ (February 2003). "Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole". Clinical Microbiology and Infection. 9 (2): 110–3. doi:10.1046/j.1469-0691.2003.00504.x. PMID 12588330.

[2] De Backer E, Dubreuil L, Brauman M, Acar J, Vaneechoutte M (May 2010). "In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis". Clinical Microbiology and Infection. 16 (5): 470–2. doi:10.1111/j.1469-0691.2009.02852.x. PMID 19548924.

[pmid35153156-3] Muzny CA, Van Gerwen OT (April 2022). "Secnidazole for Trichomoniasis in Women and Men". Sex Med Rev. 10 (2): 255–262. doi:10.1016/j.sxmr.2021.12.004. PMC 11019772. PMID 35153156. S2CID 246755406.

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