| Founded | 2006 |
|---|---|
| First season | 2006–07 |
| Country | Serbia |
| Confederation | FIBA Europe |
| Divisions | 6 |
| Number of teams | 56 |
| Level on pyramid | 4th |
| Promotion to | First Men's Regional League |
| Relegation to | Local Summer Leagues |
| Website | kss.rs |
Second Men's Regional League (Serbian Cyrillic: Друга мушка регионална лига, romanized: Druga muška regionalna liga) is the men's regional basketball league in Serbia. It is the 4th-tier of the basketball league system in Serbia. Founded in 2006, it is run by the Basketball Federation of Serbia (KSS).