Secretomics is a type of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism.[1] Secreted proteins are involved in a variety of physiological processes, including cell signaling and matrix remodeling, but are also integral to invasion and metastasis of malignant cells.[2] Secretomics has thus been especially important in the discovery of biomarkers for cancer[3] and understanding molecular basis of pathogenesis.[4][5] The analysis of the insoluble fraction of the secretome (the extracellular matrix) has been termed matrisomics.[6]
^Hathout, Yetrib (2007). "Approaches to the study of the cell secretome". Expert Review of Proteomics. 4 (2): 239–48. doi:10.1586/14789450.4.2.239. PMID17425459.
^Pavlou, Maria P.; Diamandis, Eleftherios P. (2010). "The cancer cell secretome: A good source for discovering biomarkers?". Journal of Proteomics. 73 (10): 1896–906. doi:10.1016/j.jprot.2010.04.003. PMID20394844.
^Khan, Mohd M.; Ernst, Orna; Sun, Jing; Fraser, Iain D. C.; Ernst, Robert K.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-06-24). "Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin". Journal of Molecular Biology. 430 (17): 2641–2660. doi:10.1016/j.jmb.2018.06.032. ISSN1089-8638. PMID29949751.