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| Sedative | |
|---|---|
| Drug class | |
.jpg) NOVO-SED sedative in pills. Significantly cheaper analogue of Novo-Passit® (Novo-Passit®) | |
| Clinical data | |
| Drugs.com | Drug Classes |
| External links | |
| MeSH | D006993 |
| Legal status | |
| In Wikidata | |
A sedative or tranquilliser[note 1] is a substance that induces sedation by reducing irritability[1] or excitement.[2] They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). In spite of the fact that each sedative acts in its own way, most produce relaxing effects by increasing GABA activity.[3]
This group is related to hypnotics. The term sedative describes drugs that serve to calm or relieve anxiety, whereas the term hypnotic describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness) they are often referred to collectively as sedative-hypnotic drugs.[4]
Sedatives can be used to produce an overly-calming effect (alcohol being the most common sedating drug). In the event of an overdose or if combined with another sedative, many of these drugs can cause sleep and even death.
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- ^ "Johns Hopkins Colon Cancer Center - Glossary S". Archived from the original on 1 December 2017. Retrieved 1 January 2009.
- ^ "sedative" at Dorland's Medical Dictionary
- ^ "Sedatives | Psychology Today". Psychology Today. Retrieved 20 November 2017.
- ^ Brunton, Laurence L.; Lazo, John S.; Lazo Parker, Keith L. (2006). "17: Hypnotics and Sedatives". Goodman & Gilman's The Pharmacological Basis of Therapeutics (11th ed.). The McGraw-Hill Companies, Inc. ISBN 978-0-07-146804-6. Retrieved 6 February 2014.