Selamectin

Selamectin
Clinical data
Trade namesRevolution, Stronghold, Revolt
Other names25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide[1]
AHFS/Drugs.comInternational Drug Names
License data
Routes of
administration		Topical
ATCvet code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.250.168 Edit this at Wikidata
Chemical and physical data
FormulaC43H63NO11
Molar mass769.973 g·mol−1
3D model (JSmol)
  • C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7
  • InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1 ☒N
  • Key:AFJYYKSVHJGXSN-XHKIUTQPSA-N ☒N
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Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats.[2] It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.[citation needed] It is structurally related to ivermectin and milbemycin.[citation needed] Selamectin is not approved for human use.[citation needed]

  1. ^ Bishop BF, Bruce CI, Evans NA, Goudie AC, Gration KA, Gibson SP, et al. (August 2000). "Selamectin: a novel broad-spectrum endectocide for dogs and cats". Veterinary Parasitology. 91 (3–4): 163–176. doi:10.1016/s0304-4017(00)00289-2. PMID 10940519.{{cite journal}}: CS1 maint: overridden setting (link)
  2. ^ a b "Revolution- selamectin solution". DailyMed. 1 December 2023. Retrieved 6 February 2024.
  3. ^ "Evicto EPAR". European Medicines Agency. 1 August 2019. Retrieved 26 June 2024.
  4. ^ "Stronghold EPAR". European Medicines Agency. 25 March 2008. Retrieved 29 June 2024.