| Clinical data | |
|---|---|
| Trade names | Selseb, Selsun Blue, others |
| Other names | Selenium sulfide |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682258 |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| ECHA InfoCard | 100.028.458 |
| Chemical and physical data | |
| Formula | S2Se |
| Molar mass | 143.09 g·mol−1 |
| 3D model (JSmol) | |
| Density | 3 g/cm3 |
| Melting point | 111 °C (232 °F) |
| Boiling point | 118 to 119 °C (244 to 246 °F) (decomposes) |
| Solubility in water | negligible mg/mL (20 °C) |
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Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat seborrheic dermatitis, dandruff, and pityriasis versicolor.[1][2] It is applied to the affected area as a lotion or shampoo.[3] Symptoms frequently return if treatment is stopped.[4]
Side effects may include hair discoloration, skin irritation, and risk of systemic absorption and toxicity, among others.[1] Use is not recommended in children less than 2–5 years old.[1][4] Use in pregnancy or breastfeeding has not been studied.[5] It consists of a mixture of inorganic covalent compounds having an approximate empirical formulas of SeS2.[6] Selenium disulfide acts as a keratolytic and antifungal agent.[7][8][9]
Selenium disulfide was approved for medical use in the United States at least as early as 1951.[4] It is on the World Health Organization's List of Essential Medicines.[10] Selenium disulfide is available as a generic medication and over the counter.[3]
- ^ a b c World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 297. hdl:10665/44053. ISBN 9789241547659.
- ^ Cite error: The named reference
pmid11702314was invoked but never defined (see the help page). - ^ a b Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 194. ISBN 9781284057560.
- ^ a b c "Selenium Sulfide". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
- ^ "Selenium sulfide topical Use During Pregnancy". Drugs.com. Archived from the original on 16 January 2017. Retrieved 13 January 2017.
- ^ Mitchell SC (2003). Biological Interactions Of Sulfur Compounds. CRC Press. p. 174. ISBN 9780203362525. Archived from the original on 16 January 2017.
- ^ Mitchell SC, Nickson RM, Waring RH (August 1993). "The Biological Activity of Selenium Sulfide". Sulfur Reports. 13 (2): 279–289. doi:10.1080/01961779308048957. eISSN 1029-0508. ISSN 0196-1772.
- ^ Borda LJ, Perper M, Keri JE (March 2019). "Treatment of seborrheic dermatitis: a comprehensive review". The Journal of Dermatological Treatment. 30 (2): 158–169. doi:10.1080/09546634.2018.1473554. PMID 29737895. S2CID 13686180.
- ^ Gupta AK, Madzia SE, Batra R (2004). "Etiology and management of Seborrheic dermatitis". Dermatology. 208 (2): 89–93. doi:10.1159/000076478. PMID 15056994. S2CID 22432032.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.