Separase

ESPL1
Identifiers
Aliases	ESPL1, ESP1, SEPA, EPAS1, Separase, extra spindle pole bodies like 1, separase
External IDs	OMIM: 604143; MGI: 2146156; HomoloGene: 32151; GeneCards: ESPL1; OMA:ESPL1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,293,638 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,232,792 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; jejunal mucosa; ; oral cavity; ; gonad; ; mucosa of ileum; ; embryo; ; gingival epithelium; ; amniotic fluid; ; mucosa of pharynx;
	Top expressed in
	oocyte; ; primary oocyte; ; epiblast; ; secondary oocyte; ; hand; ; ventricular zone; ; seminiferous tubule; ; superior cervical ganglion; ; spermatid; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; peptidase activity; catalytic activity; protein binding; cysteine-type endopeptidase activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; centrosome; mitotic spindle; nucleus;
Biological process	negative regulation of sister chromatid cohesion; chromosome segregation; homologous chromosome segregation; proteolysis; positive regulation of mitotic metaphase/anaphase transition; meiotic chromosome separation; meiotic spindle organization; meiosis I; mitotic sister chromatid segregation; establishment of mitotic spindle localization; apoptotic process; mitotic cell cycle; mitotic cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	9700
	105988
	ENSG00000135476
	ENSMUSG00000058290
	Q14674
	P60330
	NM_012291
	NM_001014976; NM_001356312
	NP_036423
	NP_001014976; NP_001343241
	Wikidata
View/Edit Human	View/Edit Mouse

Search
PMC	articles
PubMed	articles
NCBI	proteins

Separase
Separase
Identifiers
EC no.	3.4.22.49
CAS no.	351527-77-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase.^[5] In humans, separin is encoded by the ESPL1 gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135476 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058290 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ESPL1 - Separin - Homo sapiens (Human) - ESPL1 gene & protein". Uniprot.org. 2010-10-05. Retrieved 2016-05-14.
^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135476 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058290 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "ESPL1 - Separin - Homo sapiens (Human) - ESPL1 gene & protein". Uniprot.org. 2010-10-05. Retrieved 2016-05-14.

[pmid8724849-6] Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.

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