Sergey Smirnov may refer to:
- Sergey Smirnov (politician) (1918–2009), a Soviet state and party official
- Sergei Mikhailovich Smirnov (born 1950), Russian KGB/FSB official
- Sergei Sergeyevich Smirnov (born 1981), Russian footballer
- Sergey Sergeyevich Smirnov (1895–1947), Russian geologist
- Sergey Sergeyevich Smirnov (1915–1976), Russian writer
- Sergey Ivanovich Smirnov (1953–2006), Russian artist
- Sergey Victorovich Smirnov (1982-2020), Russian TV and voice actor
- Sergey Smirnov (shot putter) (born 1960), Soviet shot putter
- Sergey Smirnov (basketball), basketball player
- Sergei Smirnov (figure skater), Russian former pair skater
- Sergey Smirnov (rower) (born 1961), Soviet Olympic rower
- Sergey Smirnov (journalist) (born 1975), Russian journalist, editor-in-chief, MediaZona
- Sergei Smirnov, a fictional character in the anime series, Mobile Suit Gundam 00