Serum amyloid P component

APCS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
Identifiers
Aliases	APCS, HEL-S-92n, PTX2, SAP, amyloid P component, serum
External IDs	OMIM: 104770; MGI: 98229; HomoloGene: 123932; GeneCards: APCS; OMA:APCS - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 159,587,826 bp[1] End 159,588,865 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 80.33 cM Start 172,721,528 bp[2] End 172,722,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gallbladder islet of Langerhans pancreatic ductal cell body of pancreas skin of thigh human kidney cervix ectocervix Descending thoracic aorta Top expressed in left lobe of liver sexually immature organism right kidney epithelium of small intestine human fetus migratory enteric neural crest cell ureter atrioventricular junction thoracic diaphragm abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding unfolded protein binding metal ion binding virion binding complement component C1q complex binding carbohydrate binding identical protein binding low-density lipoprotein particle binding Cellular component blood microparticle extracellular matrix extracellular exosome nucleus extracellular space extracellular region collagen-containing extracellular matrix Biological process negative regulation of monocyte differentiation negative regulation of acute inflammatory response negative regulation of viral entry into host cell chaperone-mediated protein complex assembly negative regulation of viral process negative regulation of glycoprotein metabolic process protein folding acute-phase response negative regulation of exo-alpha-sialidase activity negative regulation of wound healing innate immune response complement activation, classical pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 325 20219 Ensembl ENSG00000132703 ENSMUSG00000026542 UniProt P02743 P12246 RefSeq (mRNA) NM_001639 NM_011318 RefSeq (protein) NP_001630 NP_035448 Location (UCSC) Chr 1: 159.59 – 159.59 Mb Chr 1: 172.72 – 172.72 Mb PubMed search [3] [4]
Wikidata
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The serum amyloid P component (SAP) is the identical serum form of the amyloid P component (AP), a 25 kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid".^[5] APCS is its human gene.^[6]