Sex-determining region Y protein

SRY
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HRY, 1HRZ, 1J46, 1J47, 2GZK
Identifiers
Aliases	SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
External IDs	OMIM: 480000; MGI: 98660; HomoloGene: 48168; GeneCards: SRY; OMA:SRY - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yp11.2 Start 2,786,855 bp[1] End 2,787,682 bp[1]
Gene location (Mouse) Chr. Y chromosome (mouse)[2] Band Y|Ypter Start 2,662,471 bp[2] End 2,663,658 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad tendon of biceps brachii right testis left testis skin of abdomen islet of Langerhans Achilles tendon skin of leg ventricular zone right adrenal cortex Top expressed in ankle joint ascending aorta aortic valve epithelium of small intestine cumulus cell Ileal epithelium supraoptic nucleus salivary gland condyle lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription factor binding calmodulin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm nuclear speck nucleoplasm nucleus Biological process cell differentiation regulation of transcription, DNA-templated sex differentiation transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of male gonad development male sex determination regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II central nervous system development positive regulation of gene expression neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6736 21674 Ensembl ENSG00000184895 ENSMUSG00000069036 UniProt Q05066 Q05738 RefSeq (mRNA) NM_003140 NM_011564 RefSeq (protein) NP_003131 NP_035694 Location (UCSC) Chr Y: 2.79 – 2.79 Mb Chr Y: 2.66 – 2.66 Mb PubMed search [3] [4]
Wikidata
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Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials).^[5] SRY is an intronless sex-determining gene on the Y chromosome.^[6] Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.

SRY is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the (SF-1) protein, SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9.^[7] Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now-induced Leydig cells of the testis then start secreting testosterone, while the Sertoli cells produce anti-Müllerian hormone.^[8] SRY gene effects normally take place 6–8 weeks after fetus formation which inhibits the female anatomical structural growth in males. It also works towards developing the secondary sexual characteristics of males.