Shaker (gene)

potassium voltage-gated channel, shaker-related subfamily, member 3
potassium voltage-gated channel, shaker-related subfamily, member 3
Identifiers
Symbol	KCNA3
NCBI gene	3738
HGNC	6221
OMIM	176263
RefSeq	NM_002232
UniProt	P22001
Other data
Locus	Chr. 1 p13.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

Shaker
Shaker
Identifiers
Organism	Drosophila melanogaster
Symbol	Sh
Entrez	32780
RefSeq (mRNA)	NM_167596
UniProt	P08510
Other data
Chromosome	X: 17.8 - 17.98 Mb
Structures
Search for
Structures	Swiss-model
Domains	InterPro

The shaker (Sh) gene, when mutated, causes a variety of atypical behaviors in the fruit fly, Drosophila melanogaster.^[1]^[2]^[3]^[4] Under ether anesthesia, the fly’s legs will shake (hence the name); even when the fly is unanaesthetized, it will exhibit aberrant movements. Sh-mutant flies have a shorter lifespan than regular flies; in their larvae, the repetitive firing of action potentials as well as prolonged exposure to neurotransmitters at neuromuscular junctions occurs.

In Drosophila, the shaker gene is located on the X chromosome. The closest human homolog is KCNA3.^[5]

^ Salkoff L, Wyman R (1981). "Genetic modification of potassium channels in Drosophila Shaker mutants". Nature. 293 (5829): 228–30. Bibcode:1981Natur.293..228S. doi:10.1038/293228a0. PMID 6268986. S2CID 4342210.
^ Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY (August 1987). "Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila". Science. 237 (4816): 770–5. Bibcode:1987Sci...237..770T. doi:10.1126/science.2441471. PMID 2441471.
^ Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY (January 1988). "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila". Nature. 331 (6152): 137–42. Bibcode:1988Natur.331..137S. doi:10.1038/331137a0. PMID 2448635. S2CID 4245558.
^ Lichtinghagen R, Stocker M, Wittka R, Boheim G, Stühmer W, Ferrus A, Pongs O (December 1990). "Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster". The EMBO Journal. 9 (13): 4399–407. doi:10.1002/j.1460-2075.1990.tb07890.x. PMC 552231. PMID 1702382.
^ HomoloGene: 20513

[pmid6268986-1] Salkoff L, Wyman R (1981). "Genetic modification of potassium channels in Drosophila Shaker mutants". Nature. 293 (5829): 228–30. Bibcode:1981Natur.293..228S. doi:10.1038/293228a0. PMID 6268986. S2CID 4342210.

[pmid2441471-2] Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY (August 1987). "Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila". Science. 237 (4816): 770–5. Bibcode:1987Sci...237..770T. doi:10.1126/science.2441471. PMID 2441471.

[pmid2448635-3] Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY (January 1988). "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila". Nature. 331 (6152): 137–42. Bibcode:1988Natur.331..137S. doi:10.1038/331137a0. PMID 2448635. S2CID 4245558.

[pmid1702382-4] Lichtinghagen R, Stocker M, Wittka R, Boheim G, Stühmer W, Ferrus A, Pongs O (December 1990). "Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster". The EMBO Journal. 9 (13): 4399–407. doi:10.1002/j.1460-2075.1990.tb07890.x. PMC 552231. PMID 1702382.

[Homologene-5] HomoloGene: 20513

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