Shams al-Din Isfahani (Persian: شمس الدین اصفهانی; died 1249) was a Persian vizier and military commander in medieval Anatolia. He served as deputy (na'eb) to Sultan Kaykhusraw II (r. 1237-1246) of the Seljuk Sultanate of Rum and as the commander-in-chief of his army. After the formal submission of the Sultanate to the Mongol Empire, he became deputy to the Mongol ruler Batu Khan (r. 1227–1255) in Anatolia. He later reached the apex of his power when he became the new vizier of the Sultanate of Rum, and its de facto ruler for a short period after Kaykhusraw's death.