Sharkey (Irish: Ó Searcaigh) is a surname of Irish origin. Notable people with the surname include:
- Bill Sharkey (1873–1946), Australian rules footballer
- Brendan Sharkey (born 1962), American politician
- Catherine Sharkey (born c. 1970), law professor
- Ed Sharkey (1927–2015), American former National Football League player
- Eddie Sharkey (born 1936), American professional wrestling trainer and former wrestler
- Emma Augusta Sharkey (1858–1902), American writer
- Feargal Sharkey (born 1958), lead singer of the pop punk band The Undertones
- Heather J. Sharkey (born 1967), American historian
- Jack Sharkey (1902–1994), American heavyweight boxing champion
- Jack Sharkey (footballer) (1874–1961), Australian rules footballer
- Jack Sharkey (writer) (1931–1992), American author and playwright
- Jackie Sharkey (1897–1970), Italian-born American boxer
- James A. Sharkey (born 1945), Irish historian and diplomat
- Jerry Sharkey (1942–2014), American historic preservationist and historian
- Jim Sharkey (1934–2014), Scottish footballer
- Joe Sharkey, columnist for The New York Times
- John Sharkey, Baron Sharkey (born 1947), British politician
- Jonathon Sharkey (born 1964), American professional wrestler and perennial candidate
- Kathleen Sharkey (born 1990), American field hockey player
- Kevin Sharkey (born 1961), Irish artist
- Lance Sharkey (1898–1967), Australian trade union activist, radical journalist and communist politician
- Michael Sharkey (born 1946), Australian poet, biographer, reviewer and academic
- Nick Sharkey (1943–2015), Scottish footballer
- Noel Sharkey, British computer scientist
- Pat Sharkey (born 1953), former footballer from Northern Ireland
- Patrick Sharkey (boxer) (1931–2016), Irish boxer
- Patrick Sharkey (born c. 1978), American sociologist
- Paul Sharkey (born 1974), former Australian rules footballer
- Ray Sharkey (1952–1993), American actor
- Sarah Sharkey, officer in the Royal Australian Navy
- Seymour Sharkey (1847–1929), British physician
- Tina Sharkey (born 1964), American entrepreneur
- Tom Sharkey (1873–1953), American boxer
- William J. Sharkey (US Navy officer) (1885–1918)
- William J. Sharkey (murderer) (c. 1847–?), convicted murderer and minor New York City politician
- William L. Sharkey (1798–1873), American judge and politician
Fictional characters include: