Siege of Rome may refer to:
- Siege of Rome (508 BC), by Clusium
- Siege of Rome (408), see Sack of Rome (410)
- Siege of Rome (409), see Sack of Rome (410)
- Siege of Rome (472), by Ricimer
- Siege of Rome (537–538), by the Ostrogoths
- Siege of Rome (546), by the Ostrogoths
- Siege of Rome (549–550), by the Ostrogoths
- Siege of Rome (756), by the Lombards under Aistulf
- Siege of Rome (1082–1084), by Henry IV, Holy Roman Emperor
- Siege of Rome (1849), by the French