Signal peptide peptidase

Peptidase_A22B
Identifiers
SymbolPeptidase_A22B
PfamPF04258
Pfam clanCL0130
InterProIPR007369
MEROPSA22
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Peptidase_A24
Identifiers
SymbolPeptidase_A24
PfamPF01478
Pfam clanCL0130
InterProIPR000045
MEROPSA24
OPM superfamily244
OPM protein3s0x
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane by the action of signal peptidase[1] and also plays key roles in immune surveillance and the maturation of certain viral proteins.[2]

  1. ^ Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. Bibcode:2002Sci...296.2215W. doi:10.1126/science.1070925. PMID 12077416. S2CID 45633906.
  2. ^ Martoglio B, Golde TE (October 2003). "Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs". Hum. Mol. Genet. 12 Spec No 2: R201-6. doi:10.1093/hmg/ddg303. hdl:20.500.11850/53541. PMID 12966028.