Sir Edward Littleton of Pillaton Hall, 4th Baronet, (c. 1727–1812) was a long-lived Staffordshire landowner and MP from the extended Littleton/Lyttelton family, who represented Staffordshire in the Parliament of Great Britain and the Parliament of the United Kingdom for a total of 28 years. The last of the Littleton Baronets of Pillaton Hall, he transferred the family seat from eponymous Pillaton to Teddesley Hall, and died childless, leaving the estates to his great-nephew, Edward Walhouse, who became Edward Littleton, 1st Baron Hatherton.