The Sisters of the Holy Cross are one of three Catholic congregations of religious sisters which trace their origins to the foundation of the Congregation of Holy Cross by Basil Moreau in Le Mans, France in 1837. Members designate themselves with the post-nominals CSC.
The other two congregations of religious women in the tradition of the Holy Cross Family are the Marianites of Holy Cross (New Orleans, Louisiana) and the Sisters of Holy Cross (Montreal, Quebec, Canada). The Sisters of Holy Cross motherhouse is located in Notre Dame, Indiana.
They are distinct from the Sisters of the Holy Cross Menzingen, a teaching congregation founded in Switzerland in 1844.