Smallpox demon

Smallpox demon (Japanese: 疱瘡神, Hōsōkami) or smallpox devil is a demon which was believed to be responsible for causing smallpox in medieval Japan. In those days, people tried to appease the smallpox demon by assuaging his anger, or they tried to attack the demon since they had no other effective treatment for smallpox.

Minamoto no Tametomo defeats a smallpox devil from Yoshitoshi's 36 drawings of Yokai
A smallpox demon enshrined