SoRI-9804

SoRI-9804
Names
	Preferred IUPAC name N-(Diphenylmethyl)-2-phenylquinazolin-4-amine
	Other names Benzhydryl-(2-phenyl-quinazolin-4-yl)-amine; 4-((Diphenylmethyl)amino)-2-phenylquinazoline
Identifiers
CAS Number	434326-29-1 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL305876;
ChemSpider	8105784;
PubChem CID	9930153;
CompTox Dashboard (EPA)	DTXSID401045758 ;
	InChI InChI=1S/C27H21N3/c1-4-12-20(13-5-1)25(21-14-6-2-7-15-21)29-27-23-18-10-11-19-24(23)28-26(30-27)22-16-8-3-9-17-22/h1-19,25H,(H,28,29,30) Key: LJIQXEUCYVPWRY-UHFFFAOYSA-N;
	SMILES C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=N2)NC(C4=CC=CC=C4)C5=CC=CC=C5;
Properties
Chemical formula	C27H21N3
Molar mass	387.486 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

SoRI-9804 is a positive allosteric modulator of dopamine transporters. Unlike others in its series & traditional DRI ligands, it inhibits the release of dopamine in addition to inhibiting the reuptake of released dopamine back into the transporter.^[1]

^ Rothman, Richard B.; Dersch, Christina M.; Ananthan, Subramaniam; Partilla, John S. (May 2009). "Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release". Journal of Pharmacology and Experimental Therapeutics. 329 (2): 718–28. doi:10.1124/jpet.108.149088. PMC 2672863. PMID 19244097.

[1] Rothman, Richard B.; Dersch, Christina M.; Ananthan, Subramaniam; Partilla, John S. (May 2009). "Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release". Journal of Pharmacology and Experimental Therapeutics. 329 (2): 718–28. doi:10.1124/jpet.108.149088. PMC 2672863. PMID 19244097.

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