Sodium/iodide cotransporter

SLC5A5
Identifiers
Aliases	SLC5A5, NIS, TDH1, solute carrier family 5 member 5
External IDs	OMIM: 601843; MGI: 2149330; HomoloGene: 37311; GeneCards: SLC5A5; OMA:SLC5A5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,895,174 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,345,401 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; deltoid muscle; ; mucosa of ileum; ; tibialis anterior muscle; ; body of stomach; ; testicle; ; pharynx; ; gonad; ; salivary gland; ; tonsil;
	Top expressed in
	epithelium of stomach; ; lumbar spinal ganglion; ; facial motor nucleus; ; submandibular gland; ; pyloric antrum; ; supraoptic nucleus; ; gastrula; ; Epithelium of choroid plexus; ; embryo; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; symporter activity; iodide transmembrane transporter activity; sodium:iodide symporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; extracellular vesicle; membrane; extracellular exosome; nucleus; plasma membrane;
Biological process	sodium ion transmembrane transport; sodium ion transport; ion transport; anion transmembrane transport; cellular response to gonadotropin stimulus; cellular response to cAMP; transmembrane transport; thyroid hormone generation; iodide transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6528
	114479
	ENSG00000105641
	ENSMUSG00000000792
	Q92911
	Q99PN0
	NM_000453
	NM_053248
	NP_000444
	NP_444478
	Wikidata
View/Edit Human	View/Edit Mouse

The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS),^[5] is a protein that in humans is encoded by the SLC5A5 gene.^[6]^[7]^[8] It is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations (Na⁺) for each iodide anion (I⁻) into the cell.^[9] NIS mediated uptake of iodide into follicular cells of the thyroid gland is the first step in the synthesis of thyroid hormone.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105641 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000792 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glossary, UniProt Consortium
^ "Entrez Gene: SLC5A5 solute carrier family 5 (sodium iodide symporter), member 5".
^ Dai G, Levy O, Carrasco N (February 1996). "Cloning and characterization of the thyroid iodide transporter". Nature. 379 (6564): 458–460. Bibcode:1996Natur.379..458D. doi:10.1038/379458a0. PMID 8559252. S2CID 4366019.
^ Smanik PA, Ryu KY, Theil KS, Mazzaferri EL, Jhiang SM (August 1997). "Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter". Endocrinology. 138 (8): 3555–3558. doi:10.1210/endo.138.8.5262. PMID 9231811.
^ ^a ^b Dohán O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, et al. (February 2003). "The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance". Endocrine Reviews. 24 (1): 48–77. doi:10.1210/er.2001-0029. PMID 12588808.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105641 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000792 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Glossary, UniProt Consortium

[entrez-6] "Entrez Gene: SLC5A5 solute carrier family 5 (sodium iodide symporter), member 5".

[pmid8559252-7] Dai G, Levy O, Carrasco N (February 1996). "Cloning and characterization of the thyroid iodide transporter". Nature. 379 (6564): 458–460. Bibcode:1996Natur.379..458D. doi:10.1038/379458a0. PMID 8559252. S2CID 4366019.

[pmid9231811-8] Smanik PA, Ryu KY, Theil KS, Mazzaferri EL, Jhiang SM (August 1997). "Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter". Endocrinology. 138 (8): 3555–3558. doi:10.1210/endo.138.8.5262. PMID 9231811.

[pmid12588808-9] Dohán O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, et al. (February 2003). "The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance". Endocrine Reviews. 24 (1): 48–77. doi:10.1210/er.2001-0029. PMID 12588808.

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