Sodium aurothiomalate

Sodium aurothiomalate
Clinical data
Trade names	Myocrisin
AHFS/Drugs.com	Multum Consumer Information
License data	US FDA: Gold_sodium_thiomalate;
Pregnancy; category	AU: B2; ;
Routes of; administration	Intramuscular
ATC code	M01CB01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: Discontinued;
Pharmacokinetic data
Protein binding	High
Elimination half-life	6-25 days
Excretion	Urine (60-90%), faeces (10-40%)
Identifiers
	IUPAC name Sodium 2-(auriosulfanyl)-3-carboxypropanoate;
CAS Number	12244-57-4;
PubChem CID	16760302;
ChemSpider	7827788 ;
UNII	E4768ZY6GM;
ChEBI	CHEBI:35863 ;
CompTox Dashboard (EPA)	DTXSID20896942 ;
ECHA InfoCard	100.032.242
Chemical and physical data
Formula	C4H4AuNaO4S
Molar mass	368.09 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Au+].[Na+].[O-]C(=O)C([S-])CC(=O)O;
	InChI InChI=1S/C4H6O4S.Au.Na/c5-3(6)1-2(9)4(7)8;;/h2,9H,1H2,(H,5,6)(H,7,8);;/q;2*+1/p-2 ; Key:LTEMOXGFFHXNNS-UHFFFAOYSA-L ;
	(verify)

Sodium aurothiomalate (INN, known in the United States as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects.^[2]^[3] Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern medicine.^[4]

^ ^a ^b ^c "aurothiomalate, sodium, Myochrysine (gold sodium thiomalate) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 March 2014.
^ Jessop JD, O'Sullivan MM, Lewis PA, Williams LA, Camilleri JP, Plant MJ, Coles EC (September 1998). "A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis". British Journal of Rheumatology. 37 (9): 992–1002. doi:10.1093/rheumatology/37.9.992. PMID 9783766.
^ Iqbal MS, Saeed M, Taqi SG (2008). "Erythrocyte membrane gold levels after treatment with auranofin and sodium aurothiomalate". Biological Trace Element Research. 126 (1–3): 56–64. doi:10.1007/s12011-008-8184-x. PMID 18649049. S2CID 20169992.
^ Kean WF, Kean IR (June 2008). "Clinical pharmacology of gold". Inflammopharmacology. 16 (3): 112–25. doi:10.1007/s10787-007-0021-x. PMID 18523733. S2CID 808858.

[MSR-1] "aurothiomalate, sodium, Myochrysine (gold sodium thiomalate) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 March 2014.

[2] Jessop JD, O'Sullivan MM, Lewis PA, Williams LA, Camilleri JP, Plant MJ, Coles EC (September 1998). "A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis". British Journal of Rheumatology. 37 (9): 992–1002. doi:10.1093/rheumatology/37.9.992. PMID 9783766.

[3] Iqbal MS, Saeed M, Taqi SG (2008). "Erythrocyte membrane gold levels after treatment with auranofin and sodium aurothiomalate". Biological Trace Element Research. 126 (1–3): 56–64. doi:10.1007/s12011-008-8184-x. PMID 18649049. S2CID 20169992.

[mech08-4] Kean WF, Kean IR (June 2008). "Clinical pharmacology of gold". Inflammopharmacology. 16 (3): 112–25. doi:10.1007/s10787-007-0021-x. PMID 18523733. S2CID 808858.

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